DSCR1 (also known as RCAN1) Antibody DSCR1 is a critical negative regulator of the calcineurin-dependent signaling pathway. By binding to calcineurin (a protein phosphatase) and inhibiting its activity, DSCR1 suppresses the nuclear translocation of NFAT transcription factors and the expression of downstream genes involved in T-cell activation and angiogenesis. Acting as a molecular “brake,” it helps prevent inflammation, pathological angiogenesis, and tumor growth, and is thought to contribute to the lower cancer incidence observed in Down syndrome. DSCR1 also plays important roles in neuronal function and stress responses, influencing brain processes such as memory and learning.
