Robo-1 (Roundabout homolog 1) was first identified as a neuronal axon guidance receptor in Drosophila melanogaster. It is a single-pass transmembrane protein that contains five immunoglobulin-like domains and three fibronectin type III-like domains in its extracellular region. By binding to Slit family proteins, Robo-1 regulates cell migration and tissue morphogenesis.
Product code
Pab-01
Clone
A7241A
Application
IHC, WB
Isotype
IgG1
Host animal
Mouse
Reactivity
Human
Concentration
1 mg/mL
Immunogen
The first immunoglobulin domain (Ig1; amino acids 22-113) of human ROBO1
Buffer
PBS(-), sterilized
Conjugate
non-label
Storage
Store at 4 °C for short-term use (up to 2 weeks) and at –20 °C for long-term
References
1) Hirotaka Ito, et al., Clin Cancer Res (2006) 12 (11): 3257–3264.
2) Shuying Jiang, et al., Int J Clin Exp Pathol. (2018) 11(12): 5755–5764.
